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A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 days. 5.2 Human carcinogenicity data At the present time, the weight of epidemiological evidence suggests that aniline is not a carcinogen for the human bladder. : 4 (1974) (p. 27) 5. In 1978, the results of a carcinogenesis bioassay in rats and mice given aniline hydrochloride were released. IRIS (U.S. EPA, 2007) has classified aniline as a probable human carcinogen (Group B2), based on an increased incidence of sarcomas of the spleen and other organs in two strains of rats exposed orally to aniline hydrochloride (CIIT,1982; NCI, 1978) and supporting genetic toxicity evidence. Aniline is incompatible with oxidizing agents, bases, acids, iron and iron salts, zinc, aluminium. Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg). Aniline can cause skin irritation and rash. LEL: … Learn about benzidine, exposure to which raises your risk of bladder cancer. Aniline is a chemical byproduct of treated coal tar, which was an abundant waste product of the time. • USEPA: suggests that Aniline could be a suspected carcinogen and there is no evidence of being carcinogenic by itself. The present paper shows that AZB clearly induces micronuclei in the bone marrow of rats at a dose of 375 mg/kg and above. Until recently, these inadequate experiments plus the publication of a series of epidemiologic studies that exonerated aniline as a bladder carcinogen have led to the belief that aniline is not a carcinogen. Serious poisoning may result from ingestion of 0.25 mL. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Aniline has been evaluated as a carcinogen. But interestingly, we have seen that aniline has started to appear on restricted substance lists, which … Aniline CAS RN: 62-53-3 Carcinogenicity Evidence. the industry in general does not consider aniline as a risk from a consumer safety perspective. Aniline can irritate the eyes with possible eye damage. Aniline can cause methemoglobin formation, and liver and endocrine effects. GOTS position on Aniline Aniline is known to possess slight contact sensitising potential. However, benzidine has not been sold in the United States since the mid-1970s. EPA has classified hydrazine as a Group B2, probable human carcinogen. threshold carcinogen, as confirmed by the Committee for Risk Assessment of the European Chemicals Agency (RAC) who indicated, in its opinion on restriction of substances in tattoo inks and permanent make-up8, that aniline is considered a non-threshold carcinogen. The exposure circumstance entails exposures that are carcinogenic to humans. In the past, benzidine was used to produce dyes or products used in clinical laboratories. aniline in adult man is about 0.21 mg/kg body weight Chronic exposure Anemia, headaches, tremor, parathesia, pain, narcosis or coma, and cardiac arrhythmia. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis Considered a Non Threshold carcinogen : N-Nitroso-N-methylaniline (NMA) is an esophageal carcinogen in the rat. human is 10 grams. Beginning of August 2012, 108 agents are classified in Group 1 of IARC. Aniline is classified as a suspected carcinogen (carcinogen category 2) under the Classification, Labelling and Packaging Regulation (CLP) in the EU. EPA calculated an inhalation unit risk estimate of 4.9 × 10 -3 (µg/m 3)-1. It is considered to have high acute toxicity, based on short-term animal tests in rats. ... Metolachlor can increase the incidence of liver tumors in rats and has been classified as a possible human carcinogen (Monsanto, 1991; Wilson and Takei, 1999; Heydens et al., 2010). It causes kidney, urethra, bladder, and hematological neoplasia. Ethanol is flammable and a dangerous fire risk. In addition to the concerns related to the genotoxicity and carcinogenicity, it can cause methemoglobinemia and haemolytic anaemia after long term exposure. Exposure levels at the garment stage, especially those having undergone garment-washing processes, were low. o-Toluidine is toxic and a potential human carcinogen. Chronic Effects . This category is only used when sufficient indications of carcinogenicity for humans are available. The approximate minimum lethal dose for a 150 lb. The same carcinogen can give rise to tumors of different kinds and locations, depending on the site of application, and a given type of tumor can be caused by different substances. Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, … Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. Aniline poisoning is characterized by methemoglobin formation in the blood and resulting cyanosis or blue skin. The International Agency for Research on Cancer (IAR It is rapidly absorbed by all routes and induces methemoglobinemia. Subsequent evaluations: Vol. Benzidine is a manufactured chemical. Inhaling Aniline can irritate the nose and throat. SPECIAL PRECAUTIONS: Aniline is toxic, poisonous and a potential human carcinogen. The available studies in humans are inadequate to determine whether exposure to aniline can increase the risk of developing cancer in people. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an aromatic amine-like odor. NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. ( DEL ) of intervening sequences Synonyms Phenylamine ; Aminobenzene ; Benzenamine Certified..., iron and iron salts, zinc, aluminium shows that AZB induces... Evaluate the risks based on short-term animal tests in rats and mice given aniline hydrochloride were released inducing in! A potent rat carcinogen, inducing tumours in the rat potential of benzene mild dermal sensitizer it is toxic a. Of being carcinogenic by itself of a carcinogenesis bioassay in rats the Panel concluded that aniline is toxic poisonous. 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